Association study of neuregulin 1 gene with schizophrenia
JZ Yang, TM Si, Y Ruan, YS Ling, YH Han… - Molecular …, 2003 - nature.com
JZ Yang, TM Si, Y Ruan, YS Ling, YH Han, XL Wang, M Zhou, HY Zhang, QM Kong, C Liu…
Molecular psychiatry, 2003•nature.comA number of studies have indicated that 8p22–p12 is likely to harbor schizophrenia
susceptibility loci. In this region, the candidate gene of interest, neuregulin 1 (NRG1), may
play a role in the pathogenesis of schizophrenia. Then in the present study, we performed
the linkage disequilibrium to determine the association between three genetic variants
(SNPs: rs3924999, rs2954041, SNP8NRG221533) on NRG1 gene and schizophrenia in
246 Chinese Han schizophrenic family trios using PCR-based restriction fragment length …
susceptibility loci. In this region, the candidate gene of interest, neuregulin 1 (NRG1), may
play a role in the pathogenesis of schizophrenia. Then in the present study, we performed
the linkage disequilibrium to determine the association between three genetic variants
(SNPs: rs3924999, rs2954041, SNP8NRG221533) on NRG1 gene and schizophrenia in
246 Chinese Han schizophrenic family trios using PCR-based restriction fragment length …
Abstract
A number of studies have indicated that 8p22–p12 is likely to harbor schizophrenia susceptibility loci. In this region, the candidate gene of interest, neuregulin 1 (NRG1), may play a role in the pathogenesis of schizophrenia. Then in the present study, we performed the linkage disequilibrium to determine the association between three genetic variants (SNPs: rs3924999, rs2954041, SNP8NRG221533) on NRG1 gene and schizophrenia in 246 Chinese Han schizophrenic family trios using PCR-based restriction fragment length polymorphism method and denaturing high-performance liquid chromatography. The transmission disequilibrium test analysis for each variant showed a significant difference between two transmitted alleles even after Bonferroni correction (rs3924999, P= 0.007752; rs2954041, P= 0.0009309; SNP8NRG221533, P= 0.012606). The global χ 2 test for haplotype transmission also revealed a strong association (χ 2= 46.068, df= 7, P< 0.000001). Our results suggest that the NRG1 gene may play a role in conferring susceptibility to the disease.
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