High rates of schizophrenia in adults with velo-cardio-facial syndrome
Background Velo-cardio-facial syndrome (VCFS), a syndrome characterized by an
increased frequency of schizophrenia and bipolar disorder, is associated with small
interstitial deletions of chromosome 22q11. Methods We evaluated 50 adults with VCFS
using a structured clinical interview (Schedules for Clinical Assessment in Neuropsychiatry
or Psychiatric Assessment Schedule for Adults With Developmental Disability if IQ< 50) to
establish aDSM-IVdiagnosis. The schizophrenia phenotype in individuals with VCFS and …
increased frequency of schizophrenia and bipolar disorder, is associated with small
interstitial deletions of chromosome 22q11. Methods We evaluated 50 adults with VCFS
using a structured clinical interview (Schedules for Clinical Assessment in Neuropsychiatry
or Psychiatric Assessment Schedule for Adults With Developmental Disability if IQ< 50) to
establish aDSM-IVdiagnosis. The schizophrenia phenotype in individuals with VCFS and …