Mapping quantitative traits with random and with ascertained sibships
J Peng, D Siegmund - … of the National Academy of Sciences, 2004 - National Acad Sciences
J Peng, D Siegmund
Proceedings of the National Academy of Sciences, 2004•National Acad SciencesUse of a robust score statistic based on a variance components model to map quantitative
trait loci in randomly sampled pedigrees is reviewed. Sibships ascertained through a single
proband are discussed. Under a standard assumption of multivariate normality, two
suggested methods of ascertainment correction are shown to be asymptotically equivalent
when the number of sibships is large.
trait loci in randomly sampled pedigrees is reviewed. Sibships ascertained through a single
proband are discussed. Under a standard assumption of multivariate normality, two
suggested methods of ascertainment correction are shown to be asymptotically equivalent
when the number of sibships is large.
Use of a robust score statistic based on a variance components model to map quantitative trait loci in randomly sampled pedigrees is reviewed. Sibships ascertained through a single proband are discussed. Under a standard assumption of multivariate normality, two suggested methods of ascertainment correction are shown to be asymptotically equivalent when the number of sibships is large.
National Acad Sciences
