[HTML][HTML] Genome-wide linkage scan reveals multiple susceptibility loci influencing lipid and lipoprotein levels in the Quebec Family Study
Y Bossé, YC Chagnon, JP Després, T Rice… - Journal of lipid …, 2004 - ASBMB
A genome-wide linkage study was performed to identify chromosomal regions harboring
genes influencing lipid and lipoprotein levels. Linkage analyses were conducted for four
quantitative lipoprotein/lipid traits, ie, total cholesterol, triglyceride, HDL-cholesterol (HDL-C),
and LDL-C concentrations, in 930 subjects enrolled in the Québec Family Study. A
maximum of 534 pairs of siblings from 292 nuclear families were available. Linkage was
tested using both allele-sharing and variance-component linkage methods. The strongest …
genes influencing lipid and lipoprotein levels. Linkage analyses were conducted for four
quantitative lipoprotein/lipid traits, ie, total cholesterol, triglyceride, HDL-cholesterol (HDL-C),
and LDL-C concentrations, in 930 subjects enrolled in the Québec Family Study. A
maximum of 534 pairs of siblings from 292 nuclear families were available. Linkage was
tested using both allele-sharing and variance-component linkage methods. The strongest …
