Genetic associations: false or true?
JPA Ioannidis - Trends in molecular medicine, 2003 - cell.com
Trends in molecular medicine, 2003•cell.com
Genetic association studies for multigenetic diseases are like fishing for the truth in a sea of
trillions of candidate analyses. Red herrings are unavoidably common, and bias might
cause serious misconceptions. However, a sizeable proportion of identified genetic
associations are probably true. Meta-analysis, a rigorous, comprehensive, quantitative
synthesis of all the available data, might help us to separate the true from the false.
trillions of candidate analyses. Red herrings are unavoidably common, and bias might
cause serious misconceptions. However, a sizeable proportion of identified genetic
associations are probably true. Meta-analysis, a rigorous, comprehensive, quantitative
synthesis of all the available data, might help us to separate the true from the false.
Abstract
Genetic association studies for multigenetic diseases are like fishing for the truth in a sea of trillions of candidate analyses. Red herrings are unavoidably common, and bias might cause serious misconceptions. However, a sizeable proportion of identified genetic associations are probably true. Meta-analysis, a rigorous, comprehensive, quantitative synthesis of all the available data, might help us to separate the true from the false.
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