Localization of neurofibrillary tangles and beta-amyloid plaques in the brains of living patients with Alzheimer disease
K Shoghi-Jadid, GW Small, ED Agdeppa… - The American Journal of …, 2002 - Elsevier
The authors used 2-(1-{6-[(2-[18 F] fluoroethyl)(methyl) amino]-2-naphthyl} ethylidene)
malononitrile ([18 F] FDDNP), a hydrophobic radiofluorinated derivative of 2-{1-[6-
(dimethylamino)-2-naphthyl] ethylidene} malononitrile (DDNP), in conjunction with positron
emission tomography to determine the localization and load of neurofibrillary tangles (NFTs)
and β-amyloid senile plaques (APs) in the brains of living Alzheimer disease (AD) patients.
Previous work illustrated the in vitro binding characteristics of [18 F] FDDNP to synthetic β …
malononitrile ([18 F] FDDNP), a hydrophobic radiofluorinated derivative of 2-{1-[6-
(dimethylamino)-2-naphthyl] ethylidene} malononitrile (DDNP), in conjunction with positron
emission tomography to determine the localization and load of neurofibrillary tangles (NFTs)
and β-amyloid senile plaques (APs) in the brains of living Alzheimer disease (AD) patients.
Previous work illustrated the in vitro binding characteristics of [18 F] FDDNP to synthetic β …
