Unraveling the function of GABAA receptor subtypes
W Sieghart - Trends in Pharmacological Sciences, 2000 - cell.com
Trends in Pharmacological Sciences, 2000•cell.com
GABA A receptors are Cl− channels that can be opened by GABA and are the major
inhibitory neurotransmitter receptors in the CNS. A variety of pharmacologically important
drugs, such as benzodiazepines, barbiturates, neuroactive steroids, anesthetics and
convulsants, produce at least part of their clinically relevant effects by interacting with distinct
allosteric binding sites on GABA A receptors 1.
inhibitory neurotransmitter receptors in the CNS. A variety of pharmacologically important
drugs, such as benzodiazepines, barbiturates, neuroactive steroids, anesthetics and
convulsants, produce at least part of their clinically relevant effects by interacting with distinct
allosteric binding sites on GABA A receptors 1.
Abstract
GABAA receptors are Cl− channels that can be opened by GABA and are the major inhibitory neurotransmitter receptors in the CNS. A variety of pharmacologically important drugs, such as benzodiazepines, barbiturates, neuroactive steroids, anesthetics and convulsants, produce at least part of their clinically relevant effects by interacting with distinct allosteric binding sites on GABAA receptors1.
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