Upregulation of IL-13 concentration in vivo by the IL13 variant associated with bronchial asthma
K Arima, R Umeshita-Suyama, Y Sakata… - Journal of Allergy and …, 2002 - Elsevier
Background: A substantial body of evidence exists to support the pivotal role of IL-13 in the
pathogenesis of bronchial asthma. We recently found that a variant of the IL13 gene
(Arg110Gln) is genetically associated with bronchial asthma, which is concordant with
animal experiments using IL-13 in the development of asthma. Objective: To address
whether the Gln110 variant of IL13 influences IL-13 function, contributing to the
pathogenesis of bronchial asthma, we studied the functional properties of the variant …
pathogenesis of bronchial asthma. We recently found that a variant of the IL13 gene
(Arg110Gln) is genetically associated with bronchial asthma, which is concordant with
animal experiments using IL-13 in the development of asthma. Objective: To address
whether the Gln110 variant of IL13 influences IL-13 function, contributing to the
pathogenesis of bronchial asthma, we studied the functional properties of the variant …
