An IL-13 promoter polymorphism associated with increased risk of allergic asthma
T Van der Pouw Kraan, A Van Veen, LCM Boeije… - Genes & …, 1999 - nature.com
T Van der Pouw Kraan, A Van Veen, LCM Boeije, SAP Van Tuyl, ER De Groot, SO Stapel…
Genes & Immunity, 1999•nature.comIL-13 plays a crucial role in the development of allergic asthma by several mechanisms,
including induction of IgE antibodies, airway eosinophilia and hyper-reactivity. We
previously established a deregulated production of IL-13 by T cells from allergic asthma
patients. In this report we describe the identification of a novel IL-13 promoter polymorphism
(C to T exchange) at position− 1055. The IL-13− 1055 TT genotype is associated with
allergic asthma (P= 0.002), altered regulation of IL-13 production (P< 0.002), and increased …
including induction of IgE antibodies, airway eosinophilia and hyper-reactivity. We
previously established a deregulated production of IL-13 by T cells from allergic asthma
patients. In this report we describe the identification of a novel IL-13 promoter polymorphism
(C to T exchange) at position− 1055. The IL-13− 1055 TT genotype is associated with
allergic asthma (P= 0.002), altered regulation of IL-13 production (P< 0.002), and increased …
Abstract
IL-13 plays a crucial role in the development of allergic asthma by several mechanisms, including induction of IgE antibodies, airway eosinophilia and hyper-reactivity. We previously established a deregulated production of IL-13 by T cells from allergic asthma patients. In this report we describe the identification of a novel IL-13 promoter polymorphism (C to T exchange) at position− 1055. The IL-13− 1055 TT genotype is associated with allergic asthma (P= 0.002), altered regulation of IL-13 production (P< 0.002), and increased binding of nuclear proteins to this region. we postulate that the presence of this polymorphism predisposes to the development of allergic asthma.
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