Eotaxin-2 and IL-5 cooperate in the lung to regulate IL-13 production and airway eosinophilia and hyperreactivity
M Yang, SP Hogan, S Mahalingam, SM Pope… - Journal of allergy and …, 2003 - Elsevier
BACKGROUND: Eotaxin-2 is a member of the eotaxin subfamily of CC chemokines that
display eosinophil-specific, chemotactic properties and has been associated with allergic
disorders. However, the contribution of eotaxin-2 to the development of defined pathogenic
features of allergic disease remains to be defined. OBJECTIVE: We sought to determine
whether eotaxin-2 was a cofactor with IL-5 for the regulation of pulmonary eosinophilia and
to identify the combined role of these molecules in the induction of phenotypic …
display eosinophil-specific, chemotactic properties and has been associated with allergic
disorders. However, the contribution of eotaxin-2 to the development of defined pathogenic
features of allergic disease remains to be defined. OBJECTIVE: We sought to determine
whether eotaxin-2 was a cofactor with IL-5 for the regulation of pulmonary eosinophilia and
to identify the combined role of these molecules in the induction of phenotypic …