Cardiotrophin-1: a multifunctional cytokine that signals via LIF receptor gp130 dependent pathways
D Pennica, WI Wood, KR Chien - Cytokine & growth factor reviews, 1996 - Elsevier
In a search for novel factors that induce cardiac myocyte hypertrophy, cardiotrophin-1 (CT-1)
was identified by coupling expression cloning with an embryonic stem cell-based model of
cardiogenesis. CT-1 is a new member of the IL-6 family of cytokines that induce their
biological effects through the shared signaling subunit, gp130. The expression pattern of CT-
1 and its range of activities in hematopoietic, neuronal, and developmental assays suggest
that CT-1 may play an important role in other organ systems, in addition to its actions in …
was identified by coupling expression cloning with an embryonic stem cell-based model of
cardiogenesis. CT-1 is a new member of the IL-6 family of cytokines that induce their
biological effects through the shared signaling subunit, gp130. The expression pattern of CT-
1 and its range of activities in hematopoietic, neuronal, and developmental assays suggest
that CT-1 may play an important role in other organ systems, in addition to its actions in …
