Calcineurin and calcium/calmodulin-dependent protein kinase activate distinct metabolic gene regulatory programs in cardiac muscle
To learn more about the targets of Cn (Cn) and calcium/calmodulin-dependent protein
kinase in cardiac muscle, we investigated their actions in cultured cardiac myocytes and the
hearts of mice in vivo. Adenoviral-mediated expression of constitutively active forms of either
pathway induced expression of peroxisome proliferator-activated receptor γ coactivator 1α, a
transcriptional coactivator involved in the control of multiple cellular energy metabolic
pathways in cardiac myocytes. Transcriptional profiling studies demonstrated that Cn and …
kinase in cardiac muscle, we investigated their actions in cultured cardiac myocytes and the
hearts of mice in vivo. Adenoviral-mediated expression of constitutively active forms of either
pathway induced expression of peroxisome proliferator-activated receptor γ coactivator 1α, a
transcriptional coactivator involved in the control of multiple cellular energy metabolic
pathways in cardiac myocytes. Transcriptional profiling studies demonstrated that Cn and …
