Post-translational modifications regulate microtubule function
S Westermann, K Weber - Nature reviews Molecular cell biology, 2003 - nature.com
S Westermann, K Weber
Nature reviews Molecular cell biology, 2003•nature.comThe αβ-tubulin heterodimer, the building block of microtubules, is subject to a large number
of post-translational modifications, comparable in diversity to the intensively studied histone
modifications. Although these unusual modifications are conserved throughout evolution,
their functions have remained almost completely elusive. Recently, however, important
advances in the understanding of how tubulin modifications regulate function and
organization have been made.
of post-translational modifications, comparable in diversity to the intensively studied histone
modifications. Although these unusual modifications are conserved throughout evolution,
their functions have remained almost completely elusive. Recently, however, important
advances in the understanding of how tubulin modifications regulate function and
organization have been made.
Abstract
The αβ-tubulin heterodimer, the building block of microtubules, is subject to a large number of post-translational modifications, comparable in diversity to the intensively studied histone modifications. Although these unusual modifications are conserved throughout evolution, their functions have remained almost completely elusive. Recently, however, important advances in the understanding of how tubulin modifications regulate function and organization have been made.
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