[CITATION][C] The generation of superoxide radical during the autoxidation of hemoglobin
HP Misra, I Fridovich - Journal of Biological Chemistry, 1972 - ASBMB
The autoxidation of oxyhemoglobin to methemoglobin, at pH 6.8, causes the co-oxidation of
epinephrine to adrenochrome. Part of this co-oxidation was due to a hemoglobincatalyzed
peroxidation of epinephrine and could be inhibited by catalase. The remainder of the co-
oxidation of epinephrine was inhibited by superoxide dismutase. This indicates that the
autoxidation of oxyhemoglobin results in the generation of superoxide radicals.
epinephrine to adrenochrome. Part of this co-oxidation was due to a hemoglobincatalyzed
peroxidation of epinephrine and could be inhibited by catalase. The remainder of the co-
oxidation of epinephrine was inhibited by superoxide dismutase. This indicates that the
autoxidation of oxyhemoglobin results in the generation of superoxide radicals.