Incorporating prior parameter uncertainty in the design of sampling schedules for pharmacokinetic parameter estimation experiments
DZ D'Argenio - Mathematical Biosciences, 1990 - Elsevier
An experiment design procedure is proposed for nonlinear parameter estimation studies that
formally incorporates prior parameter uncertainty. The design criterion derives from
information theory considerations and involves an asymptotic interpretation of the expected
posterior information provided by an experiment. A pharmacokinetic sample schedule
design problem is used to illustrate and evaluate this information theoretic design strategy.
The model considered is commonly used to describe the plasma concentration of a drug …
formally incorporates prior parameter uncertainty. The design criterion derives from
information theory considerations and involves an asymptotic interpretation of the expected
posterior information provided by an experiment. A pharmacokinetic sample schedule
design problem is used to illustrate and evaluate this information theoretic design strategy.
The model considered is commonly used to describe the plasma concentration of a drug …
