Monoclonal antibody induced hearing loss
TS Nair, Y Raphael, DF Dolan, TJ Parrett, LS Perlman… - Hearing research, 1995 - Elsevier
Monoclonal antibodies KHRI-3 and KHRI-5 identify antigens expressed on inner ear
supporting cells and auditory hair cells respectively. To determine if these antibodies affect
inner ear function groups of syngeneic Balb/c mice were inoculated with hybridomas KHRI-
3, KHRI-5 and other Ig-secreting hybridomas. Hybridomas UM-A9, UM-7F11, the non-
secreting SP2/0 myeloma and mice with no hybridoma were used as controls. Animals were
tested for auditory brainstem responses (ABR) for frequencies of 4, 8, 16 and 24 kHz, before …
supporting cells and auditory hair cells respectively. To determine if these antibodies affect
inner ear function groups of syngeneic Balb/c mice were inoculated with hybridomas KHRI-
3, KHRI-5 and other Ig-secreting hybridomas. Hybridomas UM-A9, UM-7F11, the non-
secreting SP2/0 myeloma and mice with no hybridoma were used as controls. Animals were
tested for auditory brainstem responses (ABR) for frequencies of 4, 8, 16 and 24 kHz, before …