[HTML][HTML] Signaling from G Protein-coupled Receptors to ERK5/Big MAPK 1 Involves Gαq and Gα12/13 Families of Heterotrimeric G Proteins: Evidence for the …
S Fukuhara, MJ Marinissen, M Chiariello… - Journal of Biological …, 2000 - ASBMB
The regulation of gene expression by cell surface receptors often involves the stimulation of
signaling pathways including one or more members of the MAPK superfamily of serine-
threonine kinases. Upon their activation in the cytosol, MAPKs can translocate to the nucleus
and affect the activity of a variety of transcription factors. Recently, it has been observed that
a novel member of the MAPK superfamily, ERK5, can be potently activated by transforming
G protein-coupled receptors (GPCRs) and that ERK5 participates in the regulation of c-jun …
signaling pathways including one or more members of the MAPK superfamily of serine-
threonine kinases. Upon their activation in the cytosol, MAPKs can translocate to the nucleus
and affect the activity of a variety of transcription factors. Recently, it has been observed that
a novel member of the MAPK superfamily, ERK5, can be potently activated by transforming
G protein-coupled receptors (GPCRs) and that ERK5 participates in the regulation of c-jun …
