[HTML][HTML] The vascular endothelial growth factor receptor Flt-1 mediates biological activities: implications for a functional role of placenta growth factor in monocyte …
Two distinct receptors for vascular endothelial growth factor (VEGF), the tyrosine kinase
receptors Flt-1 and Flk-1/KDR, have been described. In this study we show that monocytes,
in contrast to endothelium, express only the VEGF receptor Flt-1, and that this receptor
specifically binds also the VEGF homolog placenta growth factor (PlGF). Both VEGF and
PlGF stimulate tissue factor production and chemotaxis in monocytes at equivalent doses. In
contrast, endothelial cells expressing both the Flt-1 and the Flk-1/KDR receptors produce …
receptors Flt-1 and Flk-1/KDR, have been described. In this study we show that monocytes,
in contrast to endothelium, express only the VEGF receptor Flt-1, and that this receptor
specifically binds also the VEGF homolog placenta growth factor (PlGF). Both VEGF and
PlGF stimulate tissue factor production and chemotaxis in monocytes at equivalent doses. In
contrast, endothelial cells expressing both the Flt-1 and the Flk-1/KDR receptors produce …