[HTML][HTML] CASH, a novel caspase homologue with death effector domains
YV Goltsev, AV Kovalenko, E Arnold… - Journal of Biological …, 1997 - ASBMB
CASP-8 and CASP-10, members of a cysteine protease family that participates in apoptosis,
interact with MORT1/FADD, an adapter protein in the CD120a (p55 tumor necrosis factor
receptor), and CD95 (Fas/Apo-1) death-inducing signaling pathways, through a shared N-
terminal sequence motif, the death effector domain. We report cloning of two splice variants
of a novel protein, CASH, that contain two N-terminal death effector domains and can bind
through them to each other, to MORT1/FADD, to CASP-8, and to CASP-10. The unique C …
interact with MORT1/FADD, an adapter protein in the CD120a (p55 tumor necrosis factor
receptor), and CD95 (Fas/Apo-1) death-inducing signaling pathways, through a shared N-
terminal sequence motif, the death effector domain. We report cloning of two splice variants
of a novel protein, CASH, that contain two N-terminal death effector domains and can bind
through them to each other, to MORT1/FADD, to CASP-8, and to CASP-10. The unique C …
