Identification of genomic typing of non-DR3 HLA class II genes associated with myasthenia gravis
ML Vieira, S Caillat-Zucman, P Gajdos… - Journal of …, 1993 - Elsevier
HLA association with myasthenia gravis (MG) has been studied in a series of 114 patients
using class I and class II genotyping after PCR amplification. Positive association was found
with DR3, particularly in women (RR= 2.6) and in early MG onset (RR= 3.4). DRB1, DRB3,
DQB1, DQA1 and B (B8 and B18_genotyping revealed that the association was
predominantly with the B8 DRB1∗ 03 DRB3∗ 0101 DQB1∗ 0201 DQA1∗ 0501 ancestral
haplotype. This haplotype frequency was also increased in patients with thymic hyperplasia …
using class I and class II genotyping after PCR amplification. Positive association was found
with DR3, particularly in women (RR= 2.6) and in early MG onset (RR= 3.4). DRB1, DRB3,
DQB1, DQA1 and B (B8 and B18_genotyping revealed that the association was
predominantly with the B8 DRB1∗ 03 DRB3∗ 0101 DQB1∗ 0201 DQA1∗ 0501 ancestral
haplotype. This haplotype frequency was also increased in patients with thymic hyperplasia …
