[PDF][PDF] Proteasome inhibitors: from research tools to drug candidates
AF Kisselev, AL Goldberg - Chemistry & biology, 2001 - cell.com
AF Kisselev, AL Goldberg
Chemistry & biology, 2001•cell.comThe 26S proteasome is a 2.4 MDa multifunctional ATP-dependent proteolytic complex,
which degrades the majority of cellular polypeptides by an unusual enzyme mechanism.
Several groups of proteasome inhibitors have been developed and are now widely used as
research tools to study the role of the ubiquitin–proteasome pathway in various cellular
processes, and two inhibitors are now in clinical trials for treatment of multiple cancers and
stroke.
which degrades the majority of cellular polypeptides by an unusual enzyme mechanism.
Several groups of proteasome inhibitors have been developed and are now widely used as
research tools to study the role of the ubiquitin–proteasome pathway in various cellular
processes, and two inhibitors are now in clinical trials for treatment of multiple cancers and
stroke.
The 26S proteasome is a 2.4 MDa multifunctional ATP-dependent proteolytic complex, which degrades the majority of cellular polypeptides by an unusual enzyme mechanism. Several groups of proteasome inhibitors have been developed and are now widely used as research tools to study the role of the ubiquitin–proteasome pathway in various cellular processes, and two inhibitors are now in clinical trials for treatment of multiple cancers and stroke.
cell.com