Characterization of fractalkine (CX3CL1) and CX3CR1 in human coronary arteries with native atherosclerosis, diabetes mellitus, and transplant vascular disease
BWC Wong, D Wong, BM McManus - Cardiovascular Pathology, 2002 - Elsevier
Background: Fractalkine is a novel chemokine that mediates both firm adhesion of
leukocytes to the endothelium via CX3CR1 and leukocyte transmigration out of the
bloodstream. Fractalkine has recently been shown to play a role in the pathogenesis of
acute organ rejection. Since its expression is regulated by inflammatory agents such as LPS,
IL-1, and TNF-α, fractalkine involvement in atherosclerosis and transplant vascular disease
(TVD) is of particular interest. In this study, we characterized the presence of fractalkine and …
leukocytes to the endothelium via CX3CR1 and leukocyte transmigration out of the
bloodstream. Fractalkine has recently been shown to play a role in the pathogenesis of
acute organ rejection. Since its expression is regulated by inflammatory agents such as LPS,
IL-1, and TNF-α, fractalkine involvement in atherosclerosis and transplant vascular disease
(TVD) is of particular interest. In this study, we characterized the presence of fractalkine and …
