[HTML][HTML] Glucose regulates islet amyloid polypeptide gene transcription in a PDX1-and calcium-dependent manner
WM Macfarlane, SC Campbell, LJ Elrick… - Journal of Biological …, 2000 - ASBMB
Islet amyloid polypeptide (IAPP) and insulin are expressed in the β-cells of the islets of
Langerhans. They are co-secreted in response to changes in glucose concentration, and
their mRNA levels are also regulated by glucose. The promoters of both genes share similar
cis-acting sequence elements, and both bind the homeodomain transcription factor PDX1,
which plays an important role in the regulation of the insulin promoter and insulin mRNA
levels by glucose. Here we examine the role of PDX1 in the regulation of the human IAPP …
Langerhans. They are co-secreted in response to changes in glucose concentration, and
their mRNA levels are also regulated by glucose. The promoters of both genes share similar
cis-acting sequence elements, and both bind the homeodomain transcription factor PDX1,
which plays an important role in the regulation of the insulin promoter and insulin mRNA
levels by glucose. Here we examine the role of PDX1 in the regulation of the human IAPP …