ContextAlthough postmenopausal hormone replacement therapy (HRT) is widely used in
the United States, new evidence about its benefits and harms requires reconsideration of its
use for the primary prevention of chronic conditions. ObjectiveTo assess the benefits and
harms of HRT for the primary prevention of cardiovascular disease, thromboembolism,
osteoporosis, cancer, dementia, and cholecystitis by reviewing the literature, conducting
meta-analyses, and calculating outcome rates. Data SourcesAll relevant English-language …