Effect of anti-LFA-1 monoclonal antibody on rat small bowel allograft survival and circulating leukocyte populations
MJ Bowles, AG Pockley, RFM Wood - Transplant Immunology, 2000 - Elsevier
Anti-LFA-1 monoclonal antibodies (mAb) prolong graft survival in several animal models.
This study assessed the effect of an anti-LFA-1 mAb (WT. 1) on small bowel allograft
rejection, circulating leukocyte subsets and in vivo target cell antigen blockade. Heterotopic
small bowel transplantation was performed between PVG donor and DA recipient rats.
Transplanted animals received 1 mg/kg per day WT. 1 on days− 1, 0 (day of transplantation)
and 1. Three doses of WT. 1 were also administered to a group of untransplanted animals to …
This study assessed the effect of an anti-LFA-1 mAb (WT. 1) on small bowel allograft
rejection, circulating leukocyte subsets and in vivo target cell antigen blockade. Heterotopic
small bowel transplantation was performed between PVG donor and DA recipient rats.
Transplanted animals received 1 mg/kg per day WT. 1 on days− 1, 0 (day of transplantation)
and 1. Three doses of WT. 1 were also administered to a group of untransplanted animals to …
