[HTML][HTML] Coupling endoplasmic reticulum stress to the cell death program: an Apaf-1-independent intrinsic pathway
RV Rao, S Castro-Obregon, H Frankowski… - Journal of Biological …, 2002 - ASBMB
Accumulation of misfolded proteins and alterations in Ca 2+ homeostasis in the
endoplasmic reticulum (ER) causes ER stress and leads to cell death. However, the signal-
transducing events that connect ER stress to cell death pathways are incompletely
understood. To discern the pathway by which ER stress-induced cell death proceeds, we
performed studies on Apaf-1−/−(null) fibroblasts that are known to be relatively resistant to
apoptotic insults that induce the intrinsic apoptotic pathway. While these cells were resistant …
endoplasmic reticulum (ER) causes ER stress and leads to cell death. However, the signal-
transducing events that connect ER stress to cell death pathways are incompletely
understood. To discern the pathway by which ER stress-induced cell death proceeds, we
performed studies on Apaf-1−/−(null) fibroblasts that are known to be relatively resistant to
apoptotic insults that induce the intrinsic apoptotic pathway. While these cells were resistant …
