[HTML][HTML] The angiogenic factor Cyr61 activates a genetic program for wound healing in human skin fibroblasts
Cyr61 is a heparin-binding, extracellular matrix-associated protein of the CCN family, which
also includes connective tissue growth factor, Nov, WISP-1, WISP-2, and WISP-3. Cyr61 is
capable of multiple functions, including induction of angiogenesis in vivo. Purified Cyr61
mediates cell adhesion and induces adhesive signaling, stimulates cell migration, enhances
cell proliferation, and promotes cell survival in both fibroblasts and endothelial cells. In this
study, we have used cDNA array hybridization to identify genes regulated by Cyr61 in …
also includes connective tissue growth factor, Nov, WISP-1, WISP-2, and WISP-3. Cyr61 is
capable of multiple functions, including induction of angiogenesis in vivo. Purified Cyr61
mediates cell adhesion and induces adhesive signaling, stimulates cell migration, enhances
cell proliferation, and promotes cell survival in both fibroblasts and endothelial cells. In this
study, we have used cDNA array hybridization to identify genes regulated by Cyr61 in …
