[HTML][HTML] Activation of the luteinizing hormone receptor following substitution of Ser-277 with selective hydrophobic residues in the ectodomain hinge region
K Nakabayashi, M Kudo, B Kobilka… - Journal of Biological …, 2000 - ASBMB
Glycoprotein hormone receptors are G protein-coupled receptors with ligand-binding
ectodomains consisting of leucine-rich repeats. The ectodomain is connected by a
conserved cysteine-rich hinge region to the seven transmembrane (TM) region. Gain-of-
function mutants of luteinizing hormone (LH) and thyroid-stimulating hormone receptors
found in patients allowed identification of residues important for receptor activation. Based
on constitutively active mutations at Ser-281 in the hinge region of the thyroid-stimulating …
ectodomains consisting of leucine-rich repeats. The ectodomain is connected by a
conserved cysteine-rich hinge region to the seven transmembrane (TM) region. Gain-of-
function mutants of luteinizing hormone (LH) and thyroid-stimulating hormone receptors
found in patients allowed identification of residues important for receptor activation. Based
on constitutively active mutations at Ser-281 in the hinge region of the thyroid-stimulating …
