DGAT and triglyceride synthesis: a new target for obesity treatment?
HC Chen, RV Farese Jr - Trends in cardiovascular medicine, 2000 - Elsevier
Because triglycerides are considered essential for survival and their synthesis has been
thought to occur through a single mechanism, inhibiting triglyceride synthesis has been
largely unexplored as a possible target for obesity treatment. However, recent studies
indicate that mice lacking acyl CoA: diacylglycerol acyltransferase (DGAT), a key enzyme in
triglyceride synthesis, are viable and resistant to diet-induced obesity. Unexpectedly, this
resistance is caused by a mechanism involving increased energy expenditure. These …
thought to occur through a single mechanism, inhibiting triglyceride synthesis has been
largely unexplored as a possible target for obesity treatment. However, recent studies
indicate that mice lacking acyl CoA: diacylglycerol acyltransferase (DGAT), a key enzyme in
triglyceride synthesis, are viable and resistant to diet-induced obesity. Unexpectedly, this
resistance is caused by a mechanism involving increased energy expenditure. These …
