Bone loss in response to long-term glucocorticoid therapy
V LoCascio, E Bonucci, B Imbimbo, P Ballanti, S Adami… - Bone and mineral, 1990 - Elsevier
A number of studies have shown that an excess of glucocorticoids induces osteoporosis, but
the mechanism (s) and the time course of the reduction of bone mass remain uncertain. In
order to clarify this issue we carried out a longitudinal clinical and histomorphometric study
of patients requiring long-term glucocorticoid treatment. In 23 patients (9 men, 10 post-and 4
premenopausal women) biochemical and bone histomorphometric investigations were
carried out before and during treatment with 10–25 mg/day of prednisone …
the mechanism (s) and the time course of the reduction of bone mass remain uncertain. In
order to clarify this issue we carried out a longitudinal clinical and histomorphometric study
of patients requiring long-term glucocorticoid treatment. In 23 patients (9 men, 10 post-and 4
premenopausal women) biochemical and bone histomorphometric investigations were
carried out before and during treatment with 10–25 mg/day of prednisone …