The 58-kDa cellular inhibitor of the double stranded RNA-dependent protein kinase requires the tetratricopeptide repeat 6 and DnaJ motifs to stimulate protein …
NM Tang, CY Ho, MG Katze - Journal of Biological Chemistry, 1996 - ASBMB
Double stranded RNA-dependent protein kinase (PKR) is a double stranded RNA-activated,
interferon-induced serine-threonine kinase that participates in both the antiviral and
antiproliferative properties of interferon. We previously found that influenza virus inhibited
PKR function by recruiting or activating a cellular inhibitor termed P58 IPK. The present
study was undertaken to complement our earlier analyses, which demonstrated that P58 IPK
efficiently inhibited PKR autophosphorylation and activity in vitro. We now report that P58 …
interferon-induced serine-threonine kinase that participates in both the antiviral and
antiproliferative properties of interferon. We previously found that influenza virus inhibited
PKR function by recruiting or activating a cellular inhibitor termed P58 IPK. The present
study was undertaken to complement our earlier analyses, which demonstrated that P58 IPK
efficiently inhibited PKR autophosphorylation and activity in vitro. We now report that P58 …
