[HTML][HTML] Phosphoinositide 3-kinase induces scattering and tubulogenesis in epithelial cells through a novel pathway
A Khwaja, K Lehmann, BM Marte… - Journal of Biological …, 1998 - ASBMB
Hepatocyte growth factor/scatter factor (HGF/SF) treatment of the Madin-Darby canine
kidney epithelial cell line causes scattering of cells grown in monolayer culture and the
formation of branching tubules by cells grown in collagen gels. HGF/SF causes prolonged
activation of both the mitogen-activated protein (MAP) kinase extracellular signal-regulated
kinase 2 (ERK2) and the phosphoinositide 3-OH kinase (PI 3-kinase) target protein kinase B
(PKB)/Akt; inhibition of either the MAP kinase pathway by the MAP kinase/ERK kinase …
kidney epithelial cell line causes scattering of cells grown in monolayer culture and the
formation of branching tubules by cells grown in collagen gels. HGF/SF causes prolonged
activation of both the mitogen-activated protein (MAP) kinase extracellular signal-regulated
kinase 2 (ERK2) and the phosphoinositide 3-OH kinase (PI 3-kinase) target protein kinase B
(PKB)/Akt; inhibition of either the MAP kinase pathway by the MAP kinase/ERK kinase …
