The gap between the number of kidneys available for transplantation and the number of recipients awaiting a kidney is growing. Consequently there is increasing interest in the donation of marginal kidneys w1x. Kidneys have been successfully transplanted from donors with known polycystic kidney disease w2x, diabetic glomerulosclerosis w3x, and horseshoe kidneys w4x. The reuse of a transplanted kidney has also been described w5x. Resolution of glomerular disease has been reported after transplantation of organs with diabetic glomerulosclerosis w3x and mesangial IgA deposits w6x. The presence of nephrotic syndrome in the donor has been considered a contra-indication to transplantation; even a recent study of transplantation of pairs ofextended criteria'donor kidneys excluded potential donors with greater than 3 gu24 h proteinuria w7x. We have been able to identify only one previous report of transplantation of kidneys from donors with nephrotic syndrome, and involving successful transplantation of kidneys from a donor with minimalchange nephropathy; proteinuria rapidly resolved following transplantation w8x. Primary focal segmental glomerulosclerosis (FSGS) is thought to be caused by a circulating factor w9x and would therefore be expected to resolve following transplantation. We report successful renal transplantation, with resolution of proteinuria, from a cadaveric donor with FSGS who had nephrotic syndrome for 38 years.