[HTML][HTML] Vascular endothelial growth factor governs endothelial nitric-oxide synthase expression via a KDR/Flk-1 receptor and a protein kinase C signaling pathway
BQ Shen, DY Lee, TF Zioncheck - Journal of Biological Chemistry, 1999 - ASBMB
The mechanism by which vascular endothelial growth factor (VEGF) regulates endothelial
nitric-oxide synthase (eNOS) expression is presently unclear. Here we report that VEGF
treatment of bovine adrenal cortex endothelial cells resulted in a 5-fold increase in both
eNOS protein and activity. Endothelial NOS expression was maximal following 2 days of
constant VEGF exposure (500 pm) and declined to base-line levels by day 5. The elevated
eNOS protein level was sustained over the time course if VEGF was co-incubated withl-N G …
nitric-oxide synthase (eNOS) expression is presently unclear. Here we report that VEGF
treatment of bovine adrenal cortex endothelial cells resulted in a 5-fold increase in both
eNOS protein and activity. Endothelial NOS expression was maximal following 2 days of
constant VEGF exposure (500 pm) and declined to base-line levels by day 5. The elevated
eNOS protein level was sustained over the time course if VEGF was co-incubated withl-N G …