A syndrome of acute zinc loss: cerebellar dysfunction, mental changes, anorexia, and taste and smell dysfunction
RI Henkin, BM Patten, PK Re… - Archives of Neurology, 1975 - jamanetwork.com
• Oral administration of the amino acid histidine to six patients with progressive systemic
sclerosis produced anorexia, taste and smell dysfunction, changes in mentation, and
cerebellar dysfunction in each patient; these changes were associated with significant
decreases in serum zinc concentration and significant increases in urinary zinc excretion.
Administration of zinc ion, even with continued histidine administration, returned each of the
signs and symptoms to or toward normal within 8 to 24 hours in each patient at the same …
sclerosis produced anorexia, taste and smell dysfunction, changes in mentation, and
cerebellar dysfunction in each patient; these changes were associated with significant
decreases in serum zinc concentration and significant increases in urinary zinc excretion.
Administration of zinc ion, even with continued histidine administration, returned each of the
signs and symptoms to or toward normal within 8 to 24 hours in each patient at the same …
